WAPPS-Hemo

Welcome to the WAPPS-Hemo service's webpage. The WAPPS-Hemo project is a centralized, dedicated, web-accessible, actively moderated database that allows participating hemophilia centres to securely input factor VIII/IX plasma levels from sparse samples of their patients, returning individual pharmacokinetic estimates (PK). These estimates are generated by a proprietary automated population PK engine and manually validated.

The specific aims of the service are:

to empower hemophilia treatment by facilitating individual PK assessment,
to allow for the robust estimation of individual PK parameters from a reduced number of plasma samples, and
to enhance knowledge about the value and application of population PK methodology to hemophilia care.

You can find a few power point presentations about WAPPS here.

If you wish to join this project, or just learn more about it, please contact us.

Best Regards,
The WAPPS-Hemo Project

404

Centres

4150

Total Patients

8397

Total PK studies

912

PK studies
Children 0-5

2235

PK studies
Children 6-11

We have modified our data management policy to comply with international standards and ensure transparency of data handling for the WAPPS project. Please review the new policy and kindly e-sign the updated WAPPS User Agreement, which is now a requirement for every WAPPS user to be entitled to use the system.

IMPORTANT - PLEASE READ CAREFULLY: This is an Agreement to access and use the Website and is a legally binding agreement between you and McMaster University ("McMaster"). By accessing or using the Website and the Materials, as defined in section 2.1 below, you are agreeing to the terms below (INCLUDING SECTION 5.3 BELOW). You agree to comply with the terms and that the terms control your relationship with McMaster. Please read all the terms carefully. If you use the Website and/or the Materials in conjunction with other products or services, then the terms for those other products or services will also apply. If you do not agree to the terms of this Agreement, you are not authorized to use the Website and must not access and/or use the Website and/or the Materials in any capacity.

TERMS OF USE

ACCOUNT AND REGISTRATION
1. You may not use the Website or the Materials and may not accept the terms of this Agreement if (a) you are not of legal age to form a binding contract with McMaster, or (b) you are a person barred from using or accessing a website similar to this Website or using or accessing materials and documents similar to the Materials, under the applicable laws of Canada or other countries including the country in which you are resident or from which you use the Website and/or the Materials.
2. If you are using the Website and/or the Materials on behalf of an entity, you represent and warrant that you have authority to bind that entity to this Agreement and by accepting this Agreement, you are doing so on behalf of that entity (and all references to "you" in the Terms refer to that entity).
3. When creating an account for use of the Website and the Materials, you need to create a unique username and choose a password, the username you create is the only name associated with your account. Use of the Website and/or the Materials through your credentials is for your use by you only. You must not make the Website and/or the Materials available to any other person or entity or allow any other person or entity to access and/or use the Website and/or Materials using your credentials.
OWNERSHIP
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AUTHORIZED USES
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PROHIBITED USES
1. You must not:
  1. sell, download, print, distribute, reproduce, rent, modify, adapt, reverse engineer, translate, make available to anyone other than you, or otherwise distribute copies of the Website and/or the Materials. This does not apply to sharing printed reports of individual pharmacokinetic reports or treatment regimens with the appropriate patients under your discretion and sole responsibility, as you deem appropriate;
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  4. remove or obscure any copyright, trade-mark or other proprietary notices from Website and/or the Materials;
  5. otherwise use the Website and/or the Materials on behalf of any third party, with the exclusion of patients under your care as appropriate;
  6. use the Website and/or the Materials to create, develop, distribute or market any product, application or service that is competitive to McMaster and/ or its affiliates (to be determined at McMaster's sole discretion);
  7. defame, abuse, harass, stalk, or threaten others;
  8. transfer the Website and/or the Materials to any ad network, ad exchange, data broker, or other advertising or monetization-related toolset or to any other service; or
  9. use the Website and/or the Materials in any manner that makes the Website and/or the Materials available to any third party, in whole or in part, with use of your own credentials.
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1. The Website and the Materials have been developed at McMaster. McMaster is providing you the Website and the Materials "as is" with all faults and without warranty of any kind, either express or implied.
2. McMaster expressly disclaims and excludes all warranties and representations expressed or implied, including but not limited to, any implied warranties that the Website or the Materials are merchantable, accurate or fit for a particular purpose. McMaster does not warrant that the Website or the Materials will meet your requirements or that the access and/or use of the Website and the Materials will produce a desired result, or that the Website or the Materials will operate uninterrupted, or error free or that any defects in the Website or the Materials will be corrected. McMaster does not warrant that the use of the Website or the Materials will not infringe any patent, copyright or trade-mark or other rights.
3. THE INDIVIDUAL PHARMACOKINETIC REPORTS AND ANY OTHER TREATMENT REGIMEN SIMULATION OR INFORMATION PROVIDED THROUGH THIS WEBSITE ARE THE BEST ESTIMATE OBTAINED ON THE BASE OF THE DATA YOU PROVIDED AND WAPPS POPULATION MODELS. ERRORS OR IMPRECISION IN THE DATA PROVIDED AND/OR THE MODELS AND/OR THE ESTIMATION PROCESS CANNOT BE COMPLETELY EXCLUDED. THEREFORE, ANY USE OF THE MATERIALS AND/OR WEBSITE REQUIRES YOUR OWN CLINICAL JUDGMENT AND IS YOUR SOLE RESPONSIBILITY. IN THE EVENT THAT YOU DECIDE TO SHARE ANY MATERIALS WITH YOUR PATIENTS, ON PAPER OR VIA ANY DEDICATED WEBSITE OR MOBILE APP, IT IS YOUR SOLE RESPONSIBILITY TO ENSURE THAT YOUR PATIENT (OR THEIR LEGAL CUSTODIAN, WHERE APPLICABLE) UNDERSTANDS THE MATERIALS PROVIDED, AND ITS LIMITATIONS.
ASSUMPTION OF RISK
1. You assume all risk and responsibility for the selection, installation, use, quality, performance and results obtained from the Website and the Materials.
2. McMaster cannot guarantee the continued availability of the Website and/or the Materials, and may cease providing the Website and/or the Materials, if for example and without limitation, McMaster is unable to host the Website and/or the Materials on McMaster servers, in a manner acceptable to McMaster or the business model changes for the use and access of the Website and/or the Materials. Should McMaster cease providing the Website and/or the Materials, you agree and acknowledge that your access and use may stop immediately, without any forewarning or any notification to you.
PATIENT DATA
1. You agree and acknowledge that you have appropriately informed your patients, and/or obtained their consent where mandated by any locally applicable regulation, about uploading any patient data required by the website, including as but not limited to any patient identifier such as the patient e-mail address, day, month and year of birth, the patient baseline factor level, data on the infusion, concentrate name, total dose administered, blood type, body weight (kg), height, infusion day, time, duration, any number of plasma samples, measured in your routine laboratory (the "Patient Data"). You agree and acknowledge that you have appropriately informed your patients Patient Data uploaded on the WAPPS Website may be used for modeling and research purposes after appropriate de-identification procedures. Patients retain the right to erasure where applicable.
LIMITATION OF LIABILITY
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INDEMNITY
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THIRD PARTY RIGHTS
1. The Website or the Materials may be dependent on programs, operating systems or other intellectual property of third parties which may require third party Agreements. Compliance to terms and payment of fees associated with these third party Agreements are the sole responsibility of you and are not included in this Agreement.
SUPPORT
1. During the term of this Agreement, McMaster will provide any technical support or assistance to you in relation to the installation, use or access of the Website and/or the Materials. If you require assistance please contact WappsHemo@mcmasterhkr.com.
ACKNOWLEDGMENT OF MCMASTER
1. McMaster grants you the right to reference the Website or the Materials in any non-academic, non-research publication (including, electronic documents and/or websites) however you must include appropriate acknowledgment of McMaster. You agree and acknowledge that you will not make any statement regarding your use of the Website, the Materials or the Patient Data which suggests partnership with, sponsorship by, or endorsement by McMaster without McMaster's prior written approval.
PUBLICITY
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TERM AND TERMINATION
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REPRESENTATION OF AUTHORITY
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NO ASSIGNMENT
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FORCE MAJEURE
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COMPLETE AGREEMENT
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SEVERABILITY
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WAIVER
1. If either party omits or delays to require the other party to punctually fulfill any of its obligations under this Agreement, this omission or delay will not operate as a waiver by that party of its rights under this Agreement.
SURVIVAL
1. Sections 2-9 and 12-13 shall survive the termination of this Agreement.
GOVERNING LAW
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